A single dose of Bharat Biotech’s Covaxin in beforehand COVID-19-infected people elicits an identical antibody response as obtained with two doses of the vaccine in these with no earlier historical past of the illness, in response to an ICMR examine. The examine was printed within the Indian Journal of Medical Research on Saturday.
“If our preliminary findings are confirmed in large population studies, a single dose of BBV152 vaccine may be recommended to previously confirmed SARS-CoV-2 infected individuals so that the naive individuals could attain the larger benefit of a limited vaccine supply,” it stated. India’s first indigenous COVID-19 vaccine Covaxin, codenamed BBV152, was permitted by the federal government for emergency use in January. Two doses are given with a niche of 4 to 6 weeks.
The examine was undertaken to look at SARS-CoV-2specific antibody responses after day zero (baseline, earlier than vaccination), day 28 plus/minus two days post-first dose (month 1) and day 56 plus/minus two days post-first dose (month 2) of BBV152 in a bunch of healthcare professionals in addition to frontline staff. The antibody response of people with confirmed pre-vaccination SARSCoV-2 an infection was in contrast with these people with out prior proof of an infection.
As part of the examine, blood samples had been collected from 114 healthcare professionals and frontline staff who obtained Covaxin at vaccination centres in Chennai from February to May 2021. “Overall, good vaccine-induced antibody responses were seen in prior SARS-CoV-2 infected individuals, except in two, who received a single dose of BBV152 vaccine that was similar to antibody responses seen after a two-dose vaccination course administered to infection-naive individuals,” the examine said.
“Our results in a varied group of healthcare professionals and frontline workers lend support to the previous studies (albeit mainly focused on mRNA vaccines) that increased levels of SARS-CoV-2 binding and neutralizing antibodies are present after a single vaccine dose in previously infected individuals and are comparable to the levels seen after two doses in those without prior infection,” it added. The examine provides proof in help of public health-oriented and immunologically sustained vaccine methods.
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